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KMID : 0043319850080040229
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Archives of Pharmacal Research
1985 Volume.8 No. 4 p.229 ~ p.235
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Studies on Triterpenoid Corticomimetics (V) Oxidation of Presenegenin with Chromium Trioxide-Acetic Acid to Yield 11-Keto and 12-Keto Deravatives
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Han Byung-Hoon
Han Yong-Nam
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Abstract
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Oxidation of presenegenin dimethyl ester triacetate with chromium trioxide in acetic acid yielded two compounds, 11-ketone (IV) and 12-ketone (VI) derivatives. The latter was a main product. On mild alkaline hydrolysis, IV afforded 11-keto-presenegenin dimethyl ester (V), mp 232-234o, C32H48O8, whereas M did 12-keto-presenegenin dimethyl ester-12,27-hemiketal (VIII), mp 240-242o, C32H50O8.
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